Kanwal Singh
PhD
Biography
Kanwal is a Postdoctoral Fellow in Trauma and Critical Care Surgery at St. Michael’s Hospital/University of Toronto, a Defense Scientist with the DRDC and holds a Fellowship with the Canadian Blood Services. He is also a medic with the Canadian Armed Forces. Kanwal completed his PhD in Medical Sciences, specializing in thrombosis and hemostasis at McMaster University. His PhD studies focused on understanding the biochemistry and structural biology of clotting proteins.
At FIRST 60, Kanwal researches prehospital transfusion medicine and management of hemorrhage. Currently, his work focuses on developing dried plasma and next-generation hemostatic gauze, as well as studying the efficacy of whole blood in military and civilian prehospital settings.
Expertise
Hemostasis; Prehospital Blood Transfusion; Military Medicine; Blood Products; Trauma
Contact Information
Publications
Kanwal Singh, Henry T. Peng, Katy Moes, Colin A. Kretz, and Andrew Beckett. (2024). Past meets present: Reviving 80-year old Canadian dried serum from World War II and its significance in advancing modern freeze-dried plasma for prehospital care. British Journal of Haematology. 00:1-8. https://doi.org/10.1111/bjh.19298
Henry T Peng, Katy Moes, Kanwal Singh, Shawn G Rhind, Luis da Luz, and Andrew Beckett. (2024). Post-reconstitution hemostatic stability profiles of Canadian and German freeze-dried plasma. Life. 14(2), 172. https://doi.org/10.3390/life14020172
Hasam Madarati, Kanwal Singh, Taylor Sparring, Peter Andrisani, Patricia C. Liaw, Alison E. Fox-Robichaud, and Colin A. Kretz. (2023). Reviewing the dysregulation of ADAMTS13 and VWF in sepsis. Shock. DOI: 10.1097/SHK.0000000000002291
William P. Sheffield, Kanwal Singh, Andrew Beckett, and Dana V. Devine. (2023). Prehospital freeze-dried plasma in trauma: A critical review. Transfusion Medicine Reviews. https://doi.org/10.1016/j.tmrv.2023.150807
Kanwal Singh, Hasam Madarati, Sahar Sohrabipour, Taylor Sparring, Cherie Teney, and Colin A. Kretz. (2023). Metalloprotease domain latency protects ADAMTS13 against broad-spectrum inhibitors of metalloproteases while maintaining activity towards VWF. Journal of Thrombosis and Haemostasis. 21(7): 1789-1801. https://doi.org/10.1016/j.jtha.2023.03.021
Kanwal Singh, Veronica DeYoung, and Colin A. Kretz. (2022). Mechanisms of ADAMTS13 Regulation. Journal of Thrombosis and Haemostasis. 20(12): 2722-2732. https://doi.org/10.1111/jth.15873
Kanwal Singh, Taylor Sparring, Hasam Madarati, Colin A. Kretz. (2022). Review of our current understanding of ADAMTS13 and von Willebrand factor in sepsis and other critical illnesses. Rajkumar Rajendram, Vinood B. Patel, Victor R. Preedy. Biomarkers in Disease: Trauma, Injury and Critical Care. https://doi.org/10.1007/978-3-030-87302-8_36-1
Kanwal Singh, Andrew C. Kwong, Hasam Madarati, Sharumathy Kunasekaran, Taylor Sparring, Alison E. Fox-Robichaud, Patricia C. Liaw, and Colin A. Kretz. (2021). Characterization of ADAMTS13 and von Willebrand factor levels in septic and non-septic ICU patients. PLoS ONE. 16(2): e0247017. http://dx.doi.org/10.1371/journal.pone.0247017